Influence of White Matter Microstructure on Interhemispheric Processing Speed After Mild Traumatic Brain Injury Using Advanced Diffusion MRI

The corpus callosum (CC) is especially vulnerable to mild traumatic brain injury (MTBI). Since it connects left and right cerebral hemispheres, damage to the CC or neighbor white matter (WM) pathways may specifically disrupt interhemispheric communication. Here we employ a mediation framework to study the collaboration between tissue microstructure of the CC and neighbor WM pathways that may influence interhemispheric processing. Our results show different patterns in individuals with recent MTBI compared to healthy controls in terms of the relationships between callosal microstructure and interhemispheric communication mediated by other pathways, highlighting tracks specifically related to primary visual and language processes.