Quadratic phase-modulated xSPEN (QxSPEN): A new route to high resolution single-shot imaging

Single-shot cross-term SPatiotemporal ENcoding (xSPEN) is a single-shot approach to MRI with exceptional resilience to field inhomogeneities. xSPEN’s non-Fourier nature and sinc-like point-spread function demands SNR/resolution compromises which, so far, no post-processing has managed to solve. This study shows that introducing a quadratic phase modulation in conjunction with the hyperbolic phase modulation demanded by xSPEN can solve this, enabling the use of deconvolution principles providing resolution enhancement. The principles and examples of the ensuing quadratic xSPEN (QxSPEN) experiment, are presented on synthetic, phantom and human brain single-shot data.