Development and Validation of a Radiomics Model in Differentiating Sinonasal Mucosal Melanomas from Sinonasal Lymphomas

Sinonasal mucosal melanomas (SNMM) are clinically more aggressive than its cutaneous counterpart and presented markedly poor prognosis. To differentiate sinonasal melanomas from sinonasal lymphomas, a radiomics model was built using features from multi-parametric MRI, including T1-weighted imaging (T1WI), T2 weighted imaging (T2WI), DWI and C-T1WI. In this multicenter retrospective study, 189 patients diagnosed with SNMMs or sinonasal lymphoma were enrolled from three institutions. The proposed model achieved AUCs of 0.884 and 0.870 in the internal and external validation set, respectively.