Diffusion spectrum imaging at 7T for probing Restricted compartment of Textile-based Phantom

Validating mathematical models that describe the diffusion in the restricted compartment in biological tissue is an active research area. Techniques like NODDI, SMT, and CHARMED models claim to quantify restricted, hindered, and free water compartment but lacks validation on a typical clinical scanner. We present a 3D-printed phantom that uses (non)-water-filled textile-based hollow fiber with a 0.9μ diameter to validate restricted and hindered compartments. This study used a DSI-based scanning protocol and reconstruction method (GDSI and RDI) to probe the restricted compartment at a 2-6μ length scale. Scalar metrics derived from reconstruction methods show a significant difference between water-(un)filled taxons.