Adjuvant chemotherapy for breast cancer might impact cognitive function and brain structure. In this study, we investigated the cerebral microstructural changes in breast cancer survivors after adjuvant chemotherapy and the correlation with cognitive function with longitudinal study designs. The results showed brain volume reduction in thefrontal and temporal regions were also observed in patients from baseline to postchemotherapy. An association between brain volume and cognitive performance was also found in the limbic system. According to our findings, the study was useful in developing a prediction model as well as a guide for cancer treatment.
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Wu et al. (2024) studied this question.
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