The relationship between abnormal pain sensation and alterations in the central nervous system of fibromyalgia patients is unknown. In this study, diffusion tensor imaging was used to systematically investigate the alterations in white matter tracts of the pain modulatory pathways. The findings revealed the altered integrity of spinothalamic tract-thalamus, thalamus-insula tracts, tracts connected thalamus, midbrain and pons, were associated with the physical and psychological dysfunction in patients with fibromyalgia.
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Huang et al. (2024) studied this question.
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