Multi-shell DTI diffusion MRI Based Graph Theory Measures for Prediction of Cognitive Impairment in the Alzheimer’s Disease Connectome Project

This is the authors' abstract. We don't add key points for this paper.

The prevalence of Alzheimer’s Dementia (AD) is on the rise, with an estimated economic burden to the US rivaling that of diabetes. Graph theory (GT) offers topological measures that can be used to detect connectivity changes due to aging and AD related processes. We aim to investigate the utility of GT measures based on multi-shell diffusion MRI (ms-dMRI) in discriminating aging individuals with cognitive impairment (CI) from healthy controls, and to find any intrinsic differences within the cognitively impaired subjects by clustering on the GT measures.