Clinical validation study demonstrates improved lesion clarity from synthetic diffusion imaging in prostate cancer, suggesting shorter scan protocols are viable despite synthetic ADC differences.
High b-value diffusion weighted imaging is clinically challenging due to its inherently low SNR and prone to presence of severe eddy current distortion due to utility of large diffusion sensitization gradient, not to mentioned high-resolution prostate DWI. In our study, 5b-protocol rFOV-syDWIswith pros of short scan time provided better lesion clarity and higher image quality. Moreover, synthetic ADCs offered reliable and satisfactory diagnostic value as scanned 13b-protocol DWIs despite significant difference of mean and median were found between syADCb=1500 and sADCb=1500 in PCa but not in hyperplasia, indicating diagnosis withrFOV-syADCs should be careful when referring to rFOV-sADCs.
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Zhou et al. (2024) studied this question.
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