Soma and Neurite Density Imaging (SANDI) characterizes microscopic differences between two glioma mouse model subtypes

Diffusion MRI (dMRI) provides an indirect characterisation of tissue features at the microscopic-scale. The Soma and Neurite Density Imaging (SANDI) methodology was initially proposed to quantity parameters of cell soma and neurite in brain white and gray matter. Here, we investigate the potential of employing SANDI as a general representation of isotropic, restricted, highly anisotropic and isotropic Gaussian components in two mouse models of glioma, derived from two cell lines with distinct microstructure (CT2A and GL261). The results reveal differences across the two tumour subtypes which are consistent with qualitative histological assessment.