Numerous neuroimaging studies have revealed abnormalities in specific brain regions in schizophrenia (SCZ), but results have been inconsistent. We conducted a whole-brain meta-analysis on surface-based morphometry studies between patients with SCZ and healthy controls by using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software. The meta-analysis demonstrated that SCZ exhibits abnormalities in cortical thickness in the inferior frontal gyrus, insula, and superior temporal gyrus. The results expand the current understanding of cortical thickness abnormalities in patients with SCZ, which would provide promising targets for therapeutic intervention.
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Sun et al. (2024) studied this question.
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