Adult cells from transplanted bone marrow can generate new neurons in central nervous system (CNS) in rodent and human. Here we report for the first time in live mouse that white matter integrity in lethally irradiated mouse transplanted with adult mouse bone marrow (BMTX) is preserved, reflected in increased fractional anisotropy (FA) of corpus callosum post BMTX. Stable concentration of N-acetyl-aspartate (NAA) and increased FA after BMTX suggests that donor cells along with irradiation may stimulate new neuronal proliferation. Nevertheless, decreased myo-inositol concentration may reflect its cell volume regulation function as seen in morphometric adjustments in BMTX brains.
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Cui et al. (2024) studied this question.
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