Study of mouse models of lesion by using a multi technique approach.

Innovative biomarkers as well as new modalities to integrate structural information at higher level should be tuned up in order to understand the mechanisms underlying the pathology evolution. Here, we show some results obtained by integrating morphological information from X-ray phase contrast microtomography with histology combined with immunohistochemistry. Thanks to this approach, we demonstrated the possibility to use the cell number variation as a biomarker for pathological conditions.