The hippocampus plays an important role in cognition and memory. Microstructural alterations can happen in specific sub-regions within the hippocampus in normal aging. Applying more advanced diffusion models and pinpointing changes in specific locations in the hippocampus, though challenging, may offer greater insight into subfield-specific neurodegeneration. Here, we applied advanced biophysical models of dMRI and correlated tissue parameters with age across the unfolded hippocampal coordinates in 43 healthy adults covering a wide age span.
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Ma et al. (2024) studied this question.
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