Investigating the endfolial pathway of the human hippocampus using ex vivo dMRI at high spatio-angular resolution

The endfolial pathway is a collection of fibers within the hilus of the human hippocampus that forms part of the complex intra-hippocampal circuitry. We investigate this pathway using high-field (11.7 T), high spatio-angular resolution diffusion MRI (dMRI) of 3 intact, excised hippocampi. Using probabilistic tractography and computational unfolding of the hippocampal strata, we demonstrate a unique sensitivity of dMRI to the 3D trajectory of the intra-hippocampal fibers.