Functional network failure has been implicated in the pathophysiology of Alzheimer’s disease (AD). FDG-PET is a well-established tool to map the glucose hypometabolism during AD progression. MRSI indexes the neuronal loss/astrogliosis noninvasively, but has been limited to single-voxel/slice techniques. Using a high-resolution 3D MRSI technique, we evaluated the neurometabolic changes in brain networks and compared them with glucose hypometabolism. Decreases in NAA and increases in mI were found in all networks. NAA reduction followed similar patterns to the hypometabolism over cognitive decline. Combined 3D MRSI and atrophy biomarkers showed comparable performance to FDG-PET in predicting cognitive decline in AD patients.
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Li et al. (2024) studied this question.
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