Sex dimorphism in early Alzheimer’s pathology: Brain connectivity and Behavior in AppNL-F/MAPT double knock-in mice

MRI is a unique tool to study the complexity of functional and structural communication in the brain. To explore the brain architecture of a mouse model of Alzheimer's Disease and highlight sex-dimorphism in the emergence of AD-like signs, we used a recent mouse model, the APPNL-F/MAPT double knock-in (dKI). In preclinical imaging, we used resting-state graph theory approaches in a longitudinal study associated with behavioral evaluation. Functional connectivity of perirhinal, dorsal-hippocampus and midbrain nodes were implicated in early memory impairments in dKI female mice. Interestingly, perirhinal-cortex and dorsal-hippocampus are key regions for object-place associative memory and long-term object-recognition.