­Neuropathology and neurometabolites in mild cognitive impairment investigated with 11C-PiB amyloid PET and 7T MRS

Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease, is increasingly studied by multi-modal beta-amyloid (Aβ) PET and MRS. Most studies have targeted the PCC and a limited number of metabolites. In this study, we analyzed Aβ PET and 7T 1H-MRS data from the ACC and PCC of MCI patients and healthy controls, using a voxel-specific Aβ metric. Metabolite-amyloid correlations were investigated using multiple regression analysis. We report a novel finding of a differential GABA-amyloid relationship for MCI patients compared with controls in the ACC and support previous reports of amyloid relationships with NAA and myo-inositol.