Radiomics Based on Diffusion and Perfusion MRI Image: New Prognostic Biomarkers in PCNSL patients

Prognostic prediction based on clinical data and laboratory tests are facing reliability challenges for immunocompetent primary central nervous system lymphoma (PCNSL). In this study, we attempted to explore new prognostic biomarkers based on MRI-radiomics features to predict the outcomes in PCNSL. Our results showed that radio-score based on the ADC map and ASL was independent risk factors in OS and PFS predictions. Meanwhile adding radiomics features improved the model performance compared with traditional ones among which model based on ASL had better performance than ADC. So radiomics features can effectively classify different prognosis and improve the model performance in PCNSL.