Arterial spin labeling MRI can predict prognosis of patients with newly-diagnosed primary CNS lymphoma

PCNSL is a heterogeneous and aggressive non-Hodgkin lymphoma with poor prognosis. The present study revealed that 3D-ASL MR perfusion imaging-derived rCBF values pre- and posttreatment can be used as predictors for patients with newly diagnosed PCNSL. Furthermore, this is the first study identifying rCBFmean as an independent predictor for overall survival. Different from the traditional prognostic scoring system, the study provided a noninvasive MRI technique that requires no contrast agent or radiation exposure. Inclusion of the 3D-ASL sequence in routine MRI protocols is highly recommended to help to optimize individualized treatment and improve prognosis.