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Methods for early treatment response evaluation to systemic therapy of liver metastases are lacking. Tumor tissue is characterized by an increased PME/PDE ratio. However, with commonly used 31P surface coils for liver 31P MRS, the liver is not fully covered. Using an integrated 31P whole-body transmit coil in combination with a 16-channel body receive array at 7T, we were able to spatially map 31P metabolite levels throughout the whole liver in a patient with liver metastases. We found highly elevated levels of both PE/ATP and PC/ATP in liver metastases in comparison with healthy liver tissue.
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Wildenberg et al. (2024) studied this question.
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