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August 14, 2024LiversOpen Access

Targeting Autophagy for Acetaminophen-Induced Liver Injury: An Update

Kaitlyn Hinz Mengwei Niu Hong-Min Ni Wen-Xing Ding

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Abstract

Acetaminophen (APAP) overdose can induce hepatocyte necrosis and acute liver failure in experimental rodents and humans. APAP is mainly metabolized via hepatic cytochrome P450 enzymes to generate the highly reactive metabolite

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Cite This Study

Hinz et al. (2024) studied this question.

synapsesocial.com/papers/68e5c624b6db64358755ce6b https://doi.org/10.3390/livers4030027

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Intracellular Signaling Mechanisms of Acetaminophen-Induced Liver Cell DeathOriginal Research · 2005 · 529 citations
2Reprogramming Acetaminophen Metabolism via Amide-to-Thioamide Modification to Prevent Drug-Induced Liver InjuryOriginal Research · 2026
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