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December 1, 2025Food and Chemical ToxicologyOpen Access

Differential Effects on Acetaminophen-induced Nephrotoxicity and Liver Injury Following Modulation of Glutathione Resynthesis

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Authors

YEYasaman EtemadiJAJephte Y. AkakpoTFTimothy A. Fields

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Overview

Observational analysis reveals acetaminophen-induced liver injury and acute kidney injury in mice, suggesting targeted therapeutic strategies may be needed.

Key Points

  • Nephrotoxicity increased following acetaminophen overdose, with notable liver injury and kidney damage observed.
  • Severe acetaminophen overdose significantly elevated blood urea nitrogen and creatine levels, indicating severe kidney injury.
  • C57BL/6J mice model was used to assess the impact of glutathione modulation on liver and kidney effects.
  • Therapeutic strategies must address specific organ responses to acetaminophen toxicity, particularly for kidney injury.

Cite This Study

Etemadi et al. (2025) studied this question.

synapsesocial.com/papers/69402a8d2d562116f2902877https://doi.org/10.1016/j.fct.2025.115896
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