Exploring the Predictive Capability of Osteoporosis Self-Assessment Tool for Asians Score for Fragility Fractures: A Retrospective Cohort Analysis

OBJECTIVE: The primary objective of the present study was to evaluate the predictive efficacy of the Osteoporosis Self-Assessment Tool for Asians (OSTA) in identifying individuals predisposed to fragility fractures.METHODS: This retrospective cohort study involved 17,189 adults aged 50 years and older. We examined the relationship between osteoporosis risk and fragility fractures to establish fundamental insights into fragility fracture risk factors. Data were collected from the outpatient orthopedic department. The incidence rates (IRs) per person-year at risk were calculated based on the initial diagnosis of fragility fractures. Poisson regression analysis was used to ascertain the IR ratios (IRR), with adjustments made for factors including age, sex, income, occupation, comorbidities, and estrogen supplementation.RESULTS: Among the 17,189 patients identified as healthy adults at baseline, 6,996 fragility fractures were recorded. The adjusted IRR for documented fragility fractures demonstrated a significant elevation among individuals categorized as medium or high risk for osteoporosis displayed a 1.24-[95% confidence interval (CI) 1.15-1.33] and 1.66-fold (95% CI = 1.51-1.83), respectively.CONCLUSION: Our results highlight the increased risk of fragility fractures associated with medium and high-risk osteoporosis, as evaluated by OSTA and provide insights into potential strategies for mitigating the anticipated public health impact of osteoporotic fractures.