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August 13, 2024Organic Letters

A General Approach for the Synthesis of Cyanoisopropyl Bicyclo[1.1.1]pentane (BCP) Motifs by Energy Transfer Process

Lin Li Qing Pang Binbin Chen Yumiao Liu Yuxuan Zhao Jirong Wu Ge Kai Jiabin Shen Pengfei Zhang

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Abstract

Bicyclo[1.1.1]pentane (BCP) heteroaryls make up an important class of BCP derivatives in drug discovery. Herein, we report the visible-light-mediated synthesis of cyanoisopropyl BCP-heteroaryls motifs from

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Li et al. (2024) studied this question.

synapsesocial.com/papers/68e5c751b6db64358755da73 https://doi.org/10.1021/acs.orglett.4c02674

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Triplet Carbene Insertion Enables Modular Access to C2-Substituted Bicyclo[1.1.1]pentanes2025 · 36 citations
2Synthesis of Diverse Glycosyl Bicyclo[1.1.1]pentanes Enabled by Electrochemical Functionalization of [1.1.1]Propellane2025 · 20 citations
3Metal-free direct carbofunctionalization of [1.1.1]propellane and [3.1.1]propellane driven by light.2025
4A Building-Up Approach to Functionalized Bicyclo[1.1.1]pentanes Through Endo-Selective [2+2] Cycloadditions of Boron Wittig-Enabled EnamidesOriginal Research · 2026
5Bicyclo[1.1.1]pentane Ketones via Friedel-Crafts Acylation2025

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Synthesis of 1-(Halo)alkyl-3-heteroaryl Bicyclo[1.1.1]pentanes Enabled by a Photocatalytic Minisci-type Multicomponent Reaction2024
Dicarbofunctionalization of [1.1.1]Propellane: One-Step Multicomponent Approach to BCP-Aryl Derivatives2026
Rapid and Modular Access to All‐Carbon Quaternary Center‐Containing 2,2‐Disubstituted Bicyclo[1.1.1]pentanes via Cyanocarbene Addition to Bicyclo[1.1.0]butanes2025

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