Technical demonstration reveals MALDI-2-assisted oversampling for metabolite imaging at single-cell resolution, indicating improved spatial tracking of cellular metabolomes.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can provide valuable insights into the metabolome of complex biological systems such as organ tissues and cells. However, obtaining metabolite data at single-cell spatial resolutions presents a few technological challenges. Generally, spatial resolution is defined by the increment the sample stage moves between laser ablation spots. Stage movements less than the diameter of the focused laser beam (
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McKinnon et al. (2024) studied this question.
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