Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy

Emmanuel C. Patin; Pablo Nenclares; Charleen Chan Wah Hak; Magnus T. Dillon; Anton Patrikeev; Martin McLaughlin; Lorna Grove; Shane Foo; Heba Soliman; Joao P. Barata; Joanna Marsden; Holly Baldock; Jim Gkantalis; Victoria Roulstone; Joan Kyula; Amy Burley; Lisa C. Hubbard; Malin Pedersen; Simon A. Smith; Eleanor Clancy‐Thompson; Alan Melcher; Masahiro Ono; Antonio Rullan; Kevin J. Harrington

doi:10.1038/s41467-024-51236-6

Abstract

The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Here, we show that combining ATR inhibition (ATRi) with radiotherapy (RT) increases the frequency of activated NKG2A

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Patin et al. (2024) studied this question.

synapsesocial.com/papers/68e5c751b6db64358755dcc5 https://doi.org/10.1038/s41467-024-51236-6

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Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy

Abstract

Discussion

Cite This Study

Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy

Abstract

Discussion

Cite This Study

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