Genetic analysis investigates CYP3A5 variants for tacrolimus dosing in Indian renal transplant patients, highlighting the role of synergistic gene effects.
Tacrolimus (TAC) has a narrow therapeutic index and shows interindividual variabilities in its blood concentration. Although guidelines recommend a genetic variant (rs776746) to determine the optimized TAC dose, discrepancies in accuracy have been noted. Therefore, studying other variants of
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Hemani et al. (2024) studied this question.
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