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A very common infectious disease but still emerging as extensive resistant known as resistant typhoid fever, caused by gram negative Salmonella enterica serovar Typhi(S.Typhi). This bacteria invades human cells by evading host defence system with the help of virulence plasmids and clustered genes called as salmonella pathogenicity islands(SPIs).These factor help bacteria to bind with plasmid mediated antimicrobial resistance gene and enable bacterium to become resistant strain or extensively resistant. After usage of multiple drugs for enteric fever made us to introduce tetracycline as last resort drug.
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Somannavar et al. (2024) studied this question.
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