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August 12, 2024Journal of Pharmacology and Experimental TherapeuticsOpen Access

KLS-13019, a novel structural analogue of cannabidiol (CBD) and GPR55receptor antagonist, Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats.

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Authors

MIMichael IppolitoSHSean A. HaydukWKWilliam A. Kinney

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Ippolito et al. (2024) studied this question.

synapsesocial.com/papers/68e5c976b6db64358755fd67https://doi.org/10.1124/jpet.124.002190
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?2021 · 16 citations
  2. 2Cannabis-based medicines for chronic neuropathic pain in adults2018 · 572 citations
  3. 3Drug Repositioning for the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Mechanism- and Screening-Based Strategy2021 · 45 citations
  4. 4Chemotherapy-induced peripheral neuropathy2017 · 24 citations
  5. 5Cannabidiol inhibits paclitaxel‐induced neuropathic pain through 5‐<scp>HT<sub>1A</sub></scp> receptors without diminishing nervous system function or chemotherapy efficacy2013 · 284 citations