Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice

Serena L’Abbate; Giuseppina Nicolini; Francesca Forini; Elisa Lepore; Sabrina Marchetti; Virginia Unfer; Gianpiero Forte; Claudia Kusmic

doi:10.1016/j.biopha.2024.117287

August 12, 2024Biomedicine & PharmacotherapyOpen Access

Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice

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Key Points

Oral inositol supplementation effectively recovered lithium-induced cardiac dysfunction in treated animals, reversing adverse physiological changes caused by exposure.
Evaluation of 4 experimental groups with n=10 C57BL6 mice per group examined the restorative capacity of oral supplementation against lithium toxicity across cohorts.
Highlights oral inositol as a promising candidate for mitigating cardiac dysfunction caused by lithium; mouse model findings require further preclinical validation.

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Implication

Demonstrates oral inositol supplementation recovers lithium-induced cardiac dysfunctions in C57BL6 mice, suggesting a potential protective role against lithium cardiotoxicity.

Abstract

This study investigates the effects of inositol (INO) supplementation on cardiac changes caused by Li in mice. The study involved 4 groups of C57BL6 mice (n=10 each): (i) mice orally administered with Li

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L’Abbate et al. (2024) studied this question.

synapsesocial.com/papers/68e5ca68b6db6435875604a4 https://doi.org/10.1016/j.biopha.2024.117287

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Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice

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Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice

Key Points

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Implication

Abstract

Discussion

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