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August 9, 2024Open Access

Thermoneutral Housing has Limited Effects on Social Isolation-Induced Bone Loss in Male C57BL/6J Mice

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Authors

RMRebecca V. MountainRPRebecca L. PetersALAudrie L. Langlais

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Overview

Randomized trial demonstrates that thermoneutral housing fails to prevent social isolation-induced bone loss in male mice, highlighting non-thermal stress pathways.

Key Points

  • Thermoneutral housing fails to rescue social isolation-induced bone loss in male mice, leaving trabecular bone and cortical thickness significantly diminished.
  • Femoral bone mineral density and bone volume fraction declined across four weeks in single-housed mice (N=8/group) despite warm ambient housing at 28°C.
  • Assessment of glucocorticoid signaling highlights non-thermal pathways driving skeletal decline in isolated mice; mouse model, further preclinical work needed.

Cite This Study

Mountain et al. (2024) studied this question.

synapsesocial.com/papers/68e5ceb0b6db643587564ff5https://doi.org/10.1101/2024.08.09.607315
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thermoneutral housing has limited effects on social isolation-induced bone loss in male C57BL/6J mice2025 · 1 citations
  2. 28446 Thermoneutral Housing has Limited Effects on Social Isolation-Induced Bone Loss in Male C57BL/6J Mice2024
  3. 3Short- and long-term effects of social isolation on adult murine bone are sex-dependent2026
  4. 4Effects of single housing on behavior, corticosterone level and body weight in male and female mice2024 · 8 citations
  5. 5Cold exposure reduces trabecular and cortical bone mass in wildtype and Dio2-deficient mice.2026