August 8, 2024Nature Cell BiologyOpen Access

Spermidine is essential for fasting-mediated autophagy and longevity

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Authors

SHSebastian J. HoferMax Delbrück Center IDIoanna DaskalakiÉcole Polytechnique Fédérale de Lausanne MBMartina BergmannUniversity of Graz

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Implication

Preclinical study reveals spermidine-dependent autophagy and longevity in model organisms and human cells, highlighting the polyamine–hypusination axis as a conserved metabolic hub.

Key Points

Spermidine levels increase upon fasting and caloric restriction across multiple species, functioning as an indispensable driver of cellular autophagy and organismal longevity.
Genetic and pharmacological blockade of spermidine synthesis abrogates fasting-induced autophagy across yeast, nematodes, and human cells while abolishing cardioprotection in vivo.
Highlights the conserved polyamine–hypusination axis regulating eIF5A as a central metabolic control hub for fasting benefits; mouse and invertebrate models warrant human validation.

Cite This Study

Hofer et al. (2024) studied this question.

synapsesocial.com/papers/68e5cfeeb6db643587565d8d https://doi.org/10.1038/s41556-024-01468-x

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Implication

Preclinical study reveals spermidine-dependent autophagy and longevity in model organisms and human cells, highlighting the polyamine–hypusination axis as a conserved metabolic hub.

Spermidine is essential for fasting-mediated autophagy and longevity

Discussion

Member takes

Implication

Key Points

Cite This Study

Spermidine is essential for fasting-mediated autophagy and longevity

Discussion

Member takes

Implication

Key Points

Cite This Study

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