Investigation reveals necessary LRRK2 kinase activity for development and regeneration in Nematostella vectensis, highlighting mechanisms relevant to inherited Parkinson's disease.
The starlet sea anemone, Nematostella vectensis, is an emerging model organism with a high regenerative capacity, which was recently found to possess an orthologue to the human Leucine Rich Repeat Kinase 2 (LRRK2) gene. Mutations in this gene are the most common cause of inherited Parkinson's Disease (PD), highlighting the importance of understanding its function. Despite two decades of research, however, the function of LRRK2 is not well established.
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Holmes et al. (2024) studied this question.
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