Comprehensive Summary Herein, a method for the enantioselective reduction of unprotected 2‐alkylpyridines is reported for the first time. By using pinacolborane and an amide as reducing agents, a large number of 2‐alkylpiperidines were synthesized with high yields and excellent enantioselectivities via a cascade process involving 1,4‐hydroboration and subsequent transfer hydrogenation. The resulting products can be easily converted to natural alkaloids.
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Luo et al. (2024) studied this question.
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