August 8, 2024The World Journal of Biological Psychiatry

Late maternal separation provides resilience to chronic variable stress-induced anxiety- and depressive-like behaviours in male but not female mice

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Authors

RORajesh Kumar Ojha SDShweta DongreIndira Gandhi National Tribal University PSPadmasana SinghUniversity of Allahabad

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Overview

Preclinical experiment reveals late maternal separation promotes resilience against chronic variable stress in male mice, highlighting sex-dependent neural adaptations.

Key Points

Late maternal separation during postnatal days 10 to 21 protects adult male mice against chronic variable stress-induced anxiety and depressive-like behaviors.
Resilience assays demonstrated preserved open-field activity and sucrose preference alongside unaltered circulating corticosterone levels in males.
Assessment of hypothalamic tissue revealed elevated expression of neuropeptide y receptors, contrasting with decreased receptor expression in the hippocampus.
Highlights the sex-dependent neurobiological mechanisms of developmental timing on stress susceptibility; mouse model, further preclinical work needed.

Cite This Study

Ojha et al. (2024) studied this question.

synapsesocial.com/papers/68e5cfffb6db64358756684d https://doi.org/10.1080/15622975.2024.2390411

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August 8, 2024The World Journal of Biological Psychiatry

Late maternal separation provides resilience to chronic variable stress-induced anxiety- and depressive-like behaviours in male but not female mice

View Full Paper

Ask AI

Bookmark

Authors

RORajesh Kumar Ojha SDShweta DongreIndira Gandhi National Tribal University PSPadmasana SinghUniversity of Allahabad

Discussion

Member takes

Overview

Preclinical experiment reveals late maternal separation promotes resilience against chronic variable stress in male mice, highlighting sex-dependent neural adaptations.

Key Points

Late maternal separation during postnatal days 10 to 21 protects adult male mice against chronic variable stress-induced anxiety and depressive-like behaviors.
Resilience assays demonstrated preserved open-field activity and sucrose preference alongside unaltered circulating corticosterone levels in males.
Assessment of hypothalamic tissue revealed elevated expression of neuropeptide y receptors, contrasting with decreased receptor expression in the hippocampus.
Highlights the sex-dependent neurobiological mechanisms of developmental timing on stress susceptibility; mouse model, further preclinical work needed.

Cite This Study

Ojha et al. (2024) studied this question.

synapsesocial.com/papers/68e5cfffb6db64358756684d https://doi.org/10.1080/15622975.2024.2390411

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