August 7, 2024The Italian Journal of Pediatrics/Italian journal of pediatricsOpen Access

Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial

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Authors

LTLuciana TeofiliUniversità Cattolica del Sacro Cuore PPPatrizia Papacci CDCarlo DaniMassachusetts General Hospital

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Implication

Randomized double-blind trial demonstrates safety of cord blood transfusions in extremely preterm neonates, suggesting early administration may reduce severe retinopathy of prematurity.

Key Points

Allogeneic cord blood transfusions appear safe and preserve fetal hemoglobin, potentially lowering the incidence of severe retinopathy of prematurity in extremely preterm neonates.
Each adult donor transfusion increased severe retinopathy of prematurity risk by 1.66 times, whereas cord blood transfusions caused fewer cases of pulmonary hypertension.
Randomized controlled trial analysis demonstrates that early cord blood transfusions are feasible, indicating that maintaining fetal hemoglobin may mitigate retinal damage.

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Teofili et al. (2024) studied this question.

synapsesocial.com/papers/68e5d23bb6db643587567f22 https://doi.org/10.1186/s13052-024-01714-w

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Implication

Randomized double-blind trial demonstrates safety of cord blood transfusions in extremely preterm neonates, suggesting early administration may reduce severe retinopathy of prematurity.

Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial

Discussion

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Implication

Key Points

Cite This Study

Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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