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August 7, 2024Frontiers in ImmunologyOpen Access

In vitro neutralization of IL-6 receptor exacerbates damage to intestinal epithelial cells during Mycobacterium avium paratuberculosis infection

Ala’ Alhendi Saleh A. Naser

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Like TNFα, IL-6 is upregulated in Crohn's disease (CD) especially in patients associated with

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Alhendi et al. (2024) studied this question.

synapsesocial.com/papers/68e5d24cb6db643587568785 https://doi.org/10.3389/fimmu.2024.1412800

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Treg-specific IL-6R signaling: a novel role in the regulation of the intestinal epithelium2025 · 1 citations
2Interleukin-6: a potent biomarker of mycobacterial infectionIn Vitro Study · 2013 · 79 citations
3<b>Responses of intestinal organoids to infection by</b> <i> <b>Mycobacterium avium</b> </i> <b>resemble symptoms observed in Crohn’s disease</b>Original Research · 2026 · 2 citations
4Targeting epithelial IFN-I signaling restores barrier integrity in anti-TNF refractory Crohn’s diseaseOriginal Research · 2026
5Campylobacter jejuni Drives MyD88-Independent Interleukin-6 Secretion via Toll-Like Receptor 2Original Research · 2009 · 59 citations

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