Gastrointestinal (GI) disease is common in companion animals. Extensive diagnostics are required for the differentiation between GI cancer and chronic inflammatory enteropathy. This diagnostic work-up is cost-prohibitive and potentially invasive. However, reaching a final diagnosis to initiate appropriate therapeutic intervention and improve patient outcome is imperative. Thus, there is a great need for diagnostic biomarkers. One could be microRNAs, as they are promising diagnostic biomarkers. MicroRNAs are small RNAs involved with post-transcriptional gene regulation in health and disease. In both dogs and cats, microRNA expression in tissue, serum, and feces has been investigated as diagnostic biomarkers in GI disease.
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Lyngby et al. (2024) studied this question.
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