The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a very prevalent viral pathogen that can induce reproductive failure in infected sows. PRRSV infection can result in smaller litters, foetal death, late-term abortions and retarded growth of infected piglets. Not all sows respond equally to the infection partly due to genetic factors. In this study, we aimed to characterise the genetic variability of pig resilience to PRRSV infection by using a stability reproductive performance (SRP) index as a proxy of resilience. By comparing reproductive data from 183 sows, we selected 48 sows with extreme SRP values, measured as the difference in piglets lost at farrowings before and during a PRRSV outbreak. Short-read DNA fragments were sequenced from selected sows using an Illumina platform. The analysis of whole-genome sequencing information identified 16 genome regions associated with the SRP classification (cut-off P-value < 10
No takes yet. Share an insight, caveat, or question.
Laplana et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: