Hydro alcoholic infusions from fruits of Pterodon polygalaeflorus Benth, commonly known as “Sucupira-Branca", are used in Brazilian folk medicine for rheumatic problems and throat infections. Since it has been verified that furanediterpene 6α,7β-di-hydroxyvouacapan-17β-oic acid (ADV), isolated from the hexane extract of these fruits, presents anti-inflammatory, analgesic, and plant growth regulatory activity, a variety of ADV derivatives has been synthesized with the aim of obtaining more information about the structure-activity relationships of this series of compounds. In this work four new amide (4-7) derivatives of ADV have been synthesized. Their structures were established by spectroscopic data, including 2D-NMR methods.
No takes yet. Share an insight, caveat, or question.
Teixeira et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: