Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

James C. Tarr; James M. Salovich; Martin Aichinger; KyuOk Jeon; Nagarathanam Veerasamy; John Sensintaffar; Heribert Arnhof; Matthias Samwer; Plamen P. Christov; Kwangho Kim; Tobias Wunberg; Norbert Schweifer; Francesca Trapani; Allison L. Arnold; Florian Martin; Bin Zhao; Nagaraju Miriyala; Danielle Sgubin; Stuart A. Fogarty; William Moore; Gordon M. Stott; Edward T. Olejniczak; Harald Engelhardt; Dorothea Rudolph; Taekyu Lee; Darryl B. McConnell; Stephen W. Fesik

doi:10.1021/acs.jmedchem.4c01188

Abstract

Myeloid cell leukemia 1 (Mcl-1) is a key regulator of the intrinsic apoptosis pathway. Overexpression of Mcl-1 is correlated with high tumor grade, poor survival, and both intrinsic and acquired resistance to cancer therapies. Herein, we disclose the structure-guided design of a small molecule Mcl-1 inhibitor, compound

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Tarr et al. (2024) studied this question.

synapsesocial.com/papers/68e5d588b6db64358756bb4b https://doi.org/10.1021/acs.jmedchem.4c01188

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Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Abstract

Discussion

Cite This Study

Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Abstract

Discussion

Cite This Study

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