Numerical and Experimental Study on Fluid-Structure Interactions in the Oscillating Flow in a Microfluidic Device

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Microcapsules, sized 1–1000 μm, offer a core-shell structure for encapsulating diverse substances, crucial in drug delivery and various applications. This work explores microcapsule deformation in microchannels with oscillating walls, utilizing a front-tracking-based 2D membrane model for Poiseuille flow. The microcapsules are created using a needle-based device, and the shell is made of a high-precision PLA bio-based resin, encapsulating the liquid core. The microcapsules are subjected to parallel plate compression experiments to assess their mechanical properties. Numerical simulations of the compression experiment are conducted, showing stress distribution within the capsule shell. A front-tracking-based 2D membrane model was applied to investigate the deformation of the microcapsule with a thin membrane shell and a liquid core in the Poiseuille flow. The microcapsules are further tested in an oscillating microchannel under different frequencies.