Palladium‐catalyzed stereoselective olefinic C−H alkynylation of gem ‐diarylsubstituted ethylenes with propargylic alcohols was achieved to access diverse unsymmetrical 1,3‐enynes. The regio‐ and stereoselectivities were established through a 1,4‐palladium migration from aryl to vinyl in the presence of 2‐FC 6 H 4 OH as additive. Mechanistic investigations suggest that cleavage of the olefinic C−H bond might not be involved in the rate‐determining step of the catalytic process.
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Lin et al. (2024) studied this question.
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