The occurrence of ANCA-associated vasculitis (AAV) in the setting of hepatitis C virus (HCV) remains uncommon, especially without cryoglobulinemias. Here, we report a case of a 58-year-old woman diagnosed with both HCV infection and AAV concurrently. Clinical presentations included proteinuria, microscopic hematuria, elevated creatinine, and positive MPO-ANCA, with the absence of cryoglobulin. Renal biopsy revealed pauci-immune crescentic glomerulonephritis. Treatment involved anti-viral medications, followed by prednisone and cyclophosphamide. The renal function showed improvement during the follow-up.
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Yuehong Li (2024) studied this question.
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