Efficacy of Oral Brush Cytology in the Early Diagnosis of Oral Potentially Malignant Lesions a Cross Sectional Study

Background: Incidence of oral cancers and oral premalignant lesions is very high in this current technological world and also transformation into oral malignant carcinoma is erratic in patients with potentially pre - malignant lesions of the oral cavity. Tissue biopsies are needed for the current management in order to characterize the histology, grade dysplasia, and focus intervention for "high risk" lesions; however, there are few evidence-based guidelines and diagnostics available in which some non invasive techniques plays major role in early diagnosis of oral potentially malignant lesions. Aim and objectives: Evaluating the efficacy of brush biopsy in early diagnosis of potentially malignant lesions by using brush border biopsy. Methods: 30 individuals with deleterious habits were instituted for Oral brush samples using smear brushes from all participants after the detailed clinical history taken. Cytology smear were prepared for all samples and assessed for dysplastic features. Results: A significant association was observed between the cytological assessments of oral brush cytology samples and the histopathological diagnosis. In addition, there was a significant inverse correlation between the grade of oral epithelial dysplasia. The diagnostic accuracy of this approach was outstanding between the presence or absence of oral epithelial dysplasia and other malignant atypia. Conclusion: This approach presents a minimally invasive, highly accurate and non-technically demanding method for the surveillance of oral potentially malignant disorders.