Niche remodeling during aging process

Aging of hematopoietic system might result from hematopoietic stem cell (HSC) and micro-environmental alterations with changes at the location, regulation and function of HSC and their progeny. Hereby, we can state the relative contribution of the aged micro-environment and the graduate alterations which changed hematopoiesis and increased incidence of age-related diseases originating in the bone marrow environment. Here, we focus on a better understanding of the biology of aging in HSCs and their niche. In summary, studies on the micro-environment that maintains and regulates HSC and its niche suggested that micro-environmental aging contributes to declined HSC function over time. After this period, aged HSCs and their derivatives remodel the niche in changing to favor myeloid expansion.