Preclinical mouse model demonstrates mutant TP53 shifts interleukin-6 cytokine dependencies in gastric cancer, suggesting distinct therapeutic windows during tumor progression.
Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations have been clarified. Here, we establish an allelic series of mice to afford conditional expression in the glandular epithelium of Kras
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