Experimental investigation demonstrates that CD94-positive natural killer cells drive pulmonary ischaemia-reperfusion injury, highlighting a potential therapeutic target in lung transplantation.
Pulmonary ischaemia-reperfusion injury (IRI) is a major contributor to poor lung transplant outcomes. We recently demonstrated a central role of airway-centred natural killer (NK) cells in mediating IRI; however, there are no existing effective therapies for directly targeting NK cells in humans.
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Tsao et al. (2024) studied this question.
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