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August 1, 2024BMJ OpenOpen Access

Effect of henagliflozin on left ventricular mass index in dialysis patients with HFpEF (HELD-HF): protocol for a multicentre, randomised, double-blind, placebo-controlled trial

Hao Yan Wei Wang Ying Li Yinghui Qi Renhua Lu Yijun Zhou Weiming Zhang Shang Liu Huihua Pang Yan Fang Zhenyuan Li Jieying Wang Meng Jiang Jun Pu Leyi Gu Wei Fang

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Abstract

Heart failure with preserved ejection fraction (HFpEF) is a prevalent comorbidity among patients with end-stage kidney disease. Although sodium-glucose cotransporter 2 inhibitors are validated in treating heart failure and ameliorating left ventricular hypertrophy among non-dialysis patients, the effects on dialysis patients are unknown. We previously investigated the pharmacokinetics of henagliflozin in patients undergoing haemodialysis (HD) or peritoneal dialysis (PD) and clarified its safety.

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Cite This Study

Yan et al. (2024) studied this question.

synapsesocial.com/papers/68e5dd9eb6db643587573569 https://doi.org/10.1136/bmjopen-2024-087617

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effects and Safety of Henagliflozin on Cardiac Structure in Dialysis Patients with Heart Failure with Preserved Ejection FractionRCT · 2026
2Eficacy of Dapagliflozin in Patients with Heart Failure with Preserved Ejection Fraction: A Randomized Controlled Trial StudyRCT · 2026
3Empagliflozin and other SGLT2 inhibitors in patients with heart failure and preserved ejection fraction: a systematic review and meta-analysismeta-analysis · 2024 · 9 citations
4Effects of empagliflozin on cardiac structure, function and biomarkers in patients with heart failure with preserved ejection fraction: study protocol for a randomised, placebo-controlled prospective trialother · 2023 · 4 citations
5Empagliflozin in improving exercise tolerance in HFpEF: study protocol for an open-label, randomized controlled studyRCT · 2026

Effect of dapagliflozin on left ventricular mass in patients with kidney failure receiving maintenance hemodialysis: Primary results from the DAPA-HD trial2026
Effect of Empagliflozin on Hemodynamics in Patients With Heart Failure and Reduced Ejection Fraction2020
Sodium–glucose cotransporter 2 inhibitors in heart failure with preserved ejection fraction2021
Barriers and facilitators of cardiac rehabilitation focusing on underserved groups: a mixed-methods systematic reviewBMJ Open · 2026
PREGnancy, HEART Health and Cardiovascular Disease (PREG-HEART): protocol for a national, direct-to-participant prospective cohort studyBMJ Open · 2026

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