Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis

Meijiao Gong; Françoise Myster; Abdulkader Azouz; Guillem Sanchez Sanchez; Shifang Li; Benoît Charloteaux; Bin Yang; Jenna Nichols; Lucas Lefèvre; Justine Javaux; Sylvain Leemans; Olivier Nivelles; Willem Van Campe; S. Roels; Laurent Mostin; Thierry van den Berg; Andrew J. Davison; Laurent Gillet; Timothy Connelley; David Vermijlen; Stanislas Goriely; Alain Vanderplasschen; Benjamin G Dewals

doi:10.1073/pnas.2404536121

Abstract

Alcelaphine gammaherpesvirus 1 (AlHV-1) asymptomatically persists in its natural host, the wildebeest. However, cross-species transmission to cattle results in the induction of an acute and lethal peripheral T cell lymphoma-like disease (PTCL), named malignant catarrhal fever (MCF). Our previous findings demonstrated an essential role for viral genome maintenance in infected CD8

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Gong et al. (2024) studied this question.

synapsesocial.com/papers/68e5dd9eb6db6435875738b9 https://doi.org/10.1073/pnas.2404536121

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Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis

Abstract

Discussion

Cite This Study

Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis

Abstract

Discussion

Cite This Study

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